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Multimolecular Process in a Packed‐Bed Immobilized Enzyme Reactor: Numerical Simulation and Back‐Mixing Effects
Author(s) -
Guzy S.,
Saidel G. M.,
Lotan N.
Publication year - 1990
Publication title -
biotechnology progress
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.572
H-Index - 129
eISSN - 1520-6033
pISSN - 8756-7938
DOI - 10.1021/bp00002a002
Subject(s) - mixing (physics) , packed bed , diffusion , porosity , chemistry , catalysis , kinetic energy , chromatography , process (computing) , chemical engineering , mechanics , thermodynamics , materials science , computer science , engineering , physics , organic chemistry , quantum mechanics , operating system
In a previous report, we presented a new analytical model describing the performance of a packed‐bed catalytic unit, where the reaction between two cosubstrates is catalyzed by an enzyme immobilized on a porous carrier. The model explicitly takes into account the changes in concentrations of both cosubstrates along the reactor, as well as the hydrodynamic regimen (i.e., back‐mixing) prevailing in the packed bed. In the present report, and on the basis of the procedures developed, we present a detailed analysis of the performance of the reactor. With numerical simulations, the effects of internal diffusion limitations, the depth of the pores, the substrates' concentration in the feed, and kinetic parameters are evaluated. Particular attention is also given here to the back‐mixing effects prevailing in the reactor. An experimental procedure for assessing their extent is described.