Immobilization and Intracellular Delivery of an Anticancer Drug Using Mussel-Inspired Polydopamine Capsules | Zendy

Jiwei Cui | Zendy; Yan Yan | Zendy; Georgina K. Such | Zendy; Kang Liang | Zendy; Christopher J. Ochs | Zendy; Almar Postma | Zendy; Frank Caruso | Zendy

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Immobilization and Intracellular Delivery of an Anticancer Drug Using Mussel-Inspired Polydopamine Capsules

Author(s) -

Jiwei Cui,

Yan Yan,

Georgina K. Such,

Kang Liang,

Christopher J. Ochs,

Almar Postma,

Frank Caruso

Publication year - 2012

Publication title -

biomacromolecules

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.689

H-Index - 220

eISSN - 1526-4602

pISSN - 1525-7797

DOI - 10.1021/bm300835r

Subject(s) - chemistry , drug delivery , drug , hela , doxorubicin , conjugate , conjugated system , methacrylic acid , combinatorial chemistry , polymer , viability assay , biochemistry , pharmacology , organic chemistry , cell , copolymer , medicine , mathematical analysis , surgery , mathematics , chemotherapy

We report a facile approach to immobilize pH-cleavable polymer-drug conjugates in mussel-inspired polydopamine (PDA) capsules for intracellular drug delivery. Our design takes advantage of the facile PDA coating to form capsules, the chemical reactivity of PDA films, and the acid-labile groups in polymer side chains for sustained pH-induced drug release. The anticancer drug doxorubicin (Dox) was conjugated to thiolated poly(methacrylic acid) (PMA(SH)) with a pH-cleavable hydrazone bond, and then immobilized in PDA capsules via robust thiol-catechol reactions between the polymer-drug conjugate and capsule walls. The loaded Dox showed limited release at physiological pH but significant release (over 85%) at endosomal/lysosomal pH. Cell viability assays showed that Dox-loaded PDA capsules enhanced the efficacy of eradicating HeLa cancer cells compared with free drug under the same assay conditions. The reported method provides a new platform for the application of stimuli-responsive PDA capsules as drug delivery systems.

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