Global Conformational Dynamics in Ras | Zendy

Casey M. O’Connor | Zendy; Evgenii L. Kovrigin | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Global Conformational Dynamics in Ras

Author(s) -

Casey M. O’Connor,

Evgenii L. Kovrigin

Publication year - 2008

Publication title -

biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.43

H-Index - 253

eISSN - 1520-4995

pISSN - 0006-2960

DOI - 10.1021/bi801076c

Subject(s) - allosteric regulation , gtpase , gtp' , biophysics , protein dynamics , chemistry , conformational change , microbiology and biotechnology , molecular dynamics , gtp binding protein regulators , signaling proteins , dynamics (music) , function (biology) , signal transduction , protein structure , g protein , biochemistry , biology , enzyme , physics , computational chemistry , acoustics

Ras and its homologues are central to regulation of a multitude of cellular processes. Ras in complex with GTP binds and activates its downstream signaling partners. (31)P NMR studies indicated that the Ras-GTP conformation is heterogeneous on a millisecond time scale, but details of its conformational dynamics remain unknown. Here we present evidence that the conformational exchange process in human H-Ras complexed with GTP mimic GppNHp is global, encompassing most of the GTPase catalytic domain. The correlated character of conformational dynamics in Ras opens opportunities for understanding allosteric effects in Ras function.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research