Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation | Zendy

Aurora RodríguezRodríguez | Zendy; Sergey Shuvaev | Zendy; Nicholas J. Rotile | Zendy; Chloe M. Jones | Zendy; Clemens K. Probst | Zendy; Diêgo S. Ferreira | Zendy; Katherine A. GrahamO'Regan | Zendy; Eszter Boros | Zendy; Rachel S. Knipe | Zendy; Jason W. Griffith | Zendy; Andrew M. Tager | Zendy; Alexei Bogdanov | Zendy; Peter Caravan | Zendy

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Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation

Author(s) -

Aurora RodríguezRodríguez,

Sergey Shuvaev,

Nicholas J. Rotile,

Chloe M. Jones,

Clemens K. Probst,

Diêgo S. Ferreira,

Katherine A. GrahamO'Regan,

Eszter Boros,

Rachel S. Knipe,

Jason W. Griffith,

Andrew M. Tager,

Alexei Bogdanov,

Peter Caravan

Publication year - 2019

Publication title -

acs sensors

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.055

H-Index - 57

ISSN - 2379-3694

DOI - 10.1021/acssensors.9b01010

Subject(s) - peroxidase , magnetic resonance imaging , moiety , bleomycin , chemistry , inflammation , nuclear magnetic resonance , enzyme , biochemistry , medicine , immunology , stereochemistry , radiology , chemotherapy , physics

An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in r 1 at 1.4 T that was attributed to an oligomerization of the probe upon oxidation. This probe, Gd-5-HT-DOTAGA, provided specific detection of lung inflammation by MRI in bleomycin-injured mice.

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