Open AccessPeroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation
Author(s) -
Aurora Rodríguez-Rodríguez,
Sergey Shuvaev,
Nicholas J. Rotile,
Chloe Jones,
Clemens K. Probst,
Diêgo S. Ferreira,
Katherine Graham-O Regan,
Eszter Boros,
Rachel S. Knipe,
Jason W. Griffith,
Andrew M. Tager,
Alexei A. Bogdanov,
Peter Caravan
Publication year - 2019
Publication title -
acs sensors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.055
H-Index - 57
ISSN - 2379-3694
DOI - 10.1021/acssensors.9b01010
Subject(s) - peroxidase , magnetic resonance imaging , moiety , bleomycin , inflammation , nuclear magnetic resonance , chemistry , enzyme , biophysics , biochemistry , medicine , biology , stereochemistry , immunology , radiology , physics , chemotherapy
An amplifiable magnetic resonance imaging (MRI) probe that combines the stability of the macrocyclic Gd-DOTAGA core with a peroxidase-reactive 5-hydroxytryptamide (5-HT) moiety is reported. The incubation of the complex under enzymatic oxidative conditions led to a 1.7-fold increase in r 1 at 1.4 T that was attributed to an oligomerization of the probe upon oxidation. This probe, Gd-5-HT-DOTAGA, provided specific detection of lung inflammation by MRI in bleomycin-injured mice.