Molecular Imprinting of Complex Matrices at Localized Surface Plasmon Resonance Biosensors for Screening of Global Interactions of Polyphenols and Proteins | Zendy

J. Rafaela L. Guerreiro | Zendy; Vladimir E. Bochenkov | Zendy; Kasper Runager | Zendy; Hüsnü Aslan | Zendy; Mingdong Dong | Zendy; Jan J. Enghild | Zendy; Víctor de Freitas | Zendy; M. Goreti F. Sales | Zendy; Duncan S. Sutherland | Zendy

Open Access

Molecular Imprinting of Complex Matrices at Localized Surface Plasmon Resonance Biosensors for Screening of Global Interactions of Polyphenols and Proteins

Author(s) -

J. Rafaela L. Guerreiro,

Vladimir E. Bochenkov,

Kasper Runager,

Hüsnü Aslan,

Mingdong Dong,

Jan J. Enghild,

Víctor de Freitas,

M. Goreti F. Sales,

Duncan S. Sutherland

Publication year - 2015

Publication title -

acs sensors

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.055

H-Index - 57

ISSN - 2379-3694

DOI - 10.1021/acssensors.5b00054

Subject(s) - surface plasmon resonance , biosensor , polyphenol , molecular imprinting , chemistry , catechin , bioavailability , molecularly imprinted polymer , nanotechnology , biophysics , combinatorial chemistry , materials science , biochemistry , nanoparticle , bioinformatics , selectivity , biology , antioxidant , catalysis

Molecular imprinting polymers (MIP) have been applied to capture and stabilize complex protein matrices at plasmonic sensor surfaces. Ultrathin MIP layers at the surface of gold nanodisks enable the label free quantification of global interactions of polyphenols with protein mixtures. Separate polyphenols (catechin, procyanidin B3- catechin dimer, and PGG-pentagalloyl glucose) give specific and different binding levels to the MIP supported saliva plasmonic sensor. The demonstrated biosensor has application to study bioavailability of polyphenols or evaluation of local retention of small drug molecules.info:eu-repo/semantics/publishedVersio

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