Open AccessIn Vitro to in Vivo Translation of Allosteric Modulator Concentration-Effect Relationships: Implications for Drug Discovery
Author(s) -
Karen J. Gregory,
Thomas M. Bridges,
Rocco G. Gogliotti,
Shaun R. Stauffer,
Meredith J. Noetzel,
Carrie K. Jones,
Craig W. Lindsley,
P. Jeffrey Conn,
Colleen M. Niswender
Publication year - 2019
Publication title -
acs pharmacology and translational science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.271
H-Index - 10
ISSN - 2575-9108
DOI - 10.1021/acsptsci.9b00062
Subject(s) - in vivo , allosteric modulator , allosteric regulation , in vitro , pharmacology , drug discovery , chemistry , cooperativity , glutamate receptor , druggability , biology , neuroscience , receptor , biophysics , biochemistry , microbiology and biotechnology , gene
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