Open AccessIntramolecular Hydrogen-Bond Activation: Strategies, Benefits, and Influence in Catalysis
Author(s) -
Andrea Guerrero-Corella,
Alberto Fraile,
José V. Alemán
Publication year - 2022
Publication title -
acs organic and inorganic au
Language(s) - English
Resource type - Journals
ISSN - 2694-247X
DOI - 10.1021/acsorginorgau.1c00053
Subject(s) - intramolecular force , reactivity (psychology) , catalysis , reagent , chemistry , hydrogen bond , combinatorial chemistry , organocatalysis , photochemistry , molecule , organic chemistry , enantioselective synthesis , medicine , alternative medicine , pathology
The activation of molecules through intramolecular hydrogen-bond formation to promote chemical reactions appears as a suitable strategy in organic synthesis, especially for the preparation of chiral compounds under metal and organocatalytic conditions. The use of this interaction has enabled reactivity enhancement of reagents, as well as stabilization of the chemical species and enantiocontrol of the processes.