Lewis Acid-Catalyzed Enantioselective Friedel–Crafts Alkylation of Pyrrole in Water | Zendy

Jianan Sun | Zendy; Yang Gui | Zendy; Yekai Huang | Zendy; Jindong Li | Zendy; Zhenggen Zha | Zendy; Yu Yang | Zendy; Zhiyong Wang | Zendy

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Lewis Acid-Catalyzed Enantioselective Friedel–Crafts Alkylation of Pyrrole in Water

Author(s) -

Jianan Sun,

Yang Gui,

Yekai Huang,

Jindong Li,

Zhenggen Zha,

Yu Yang,

Zhiyong Wang

Publication year - 2020

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b04115

Subject(s) - friedel–crafts reaction , alkylation , enantioselective synthesis , pyrrole , catalysis , lewis acids and bases , pyridine , chemistry , organic chemistry , chloroform

Highly enantioselective Friedel-Crafts alkylation of pyrroles with 2-enoyl-pyridine N -oxides in water/chloroform (10:1) was developed under catalysis of Lewis acid. The Friedel-Crafts alkylation products can be obtained in high yields and excellent enantioselectivities. Moreover, several control experiments were carried out to study the reaction mechanism.

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