Phosphine-Free Ru-Catalyzed Regio- and Stereoselective Addition of Benzoic Acids to Trifluoromethylated Alkynes toward Facile Access to Trifluoromethyl Group-Substituted (E)-Enol Esters | Zendy

Guangyuan Liu | Zendy; Xingxing Zhang | Zendy; Guanghua Kuang | Zendy; Naihao Lu | Zendy; Yang Fu | Zendy; Yiyuan Peng | Zendy; Qiang Xiao | Zendy; Yirong Zhou | Zendy

Open Access

Phosphine-Free Ru-Catalyzed Regio- and Stereoselective Addition of Benzoic Acids to Trifluoromethylated Alkynes toward Facile Access to Trifluoromethyl Group-Substituted (E)-Enol Esters

Author(s) -

Guangyuan Liu,

Xingxing Zhang,

Guanghua Kuang,

Naihao Lu,

Yang Fu,

Yiyuan Peng,

Qiang Xiao,

Yirong Zhou

Publication year - 2020

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b03936

Subject(s) - chemistry , trifluoromethyl , enol , stereoselectivity , catalysis , carbene , substrate (aquarium) , phosphine , medicinal chemistry , ruthenium , salt (chemistry) , regioselectivity , organic chemistry , alkyl , oceanography , geology

A combination of ruthenium catalyst with silver salt and copper salt was proved to be a highly efficient protocol for the direct addition reaction of benzoic acids with unsymmetrical trifluoromethylated internal alkynes. Diverse trifluoromethyl group-substituted ( E )-enol esters were readily obtained for a broad substrate scope in moderate to good yields with excellent regio- and stereoselectivities under mild reaction conditions.

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