Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as 18F-Labeled Positron Emission Tomography Probes via I-SPANC | Zendy

Sara Ghiassian | Zendy; Lihai Yu | Zendy; Pierangelo Gobbo | Zendy; Ali Nazemi | Zendy; Tommaso Romagnoli | Zendy; Wilson Luo | Zendy; Leonard G. Luyt | Zendy; Mark S. Workentin | Zendy

Open Access

Nitrone-Modified Gold Nanoparticles: Synthesis, Characterization, and Their Potential as ¹⁸F-Labeled Positron Emission Tomography Probes via I-SPANC

Author(s) -

Sara Ghiassian,

Lihai Yu,

Pierangelo Gobbo,

Ali Nazemi,

Tommaso Romagnoli,

Wilson Luo,

Leonard G. Luyt,

Mark S. Workentin

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b02322

Subject(s) - bioorthogonal chemistry , nitrone , nanoparticle , alkyne , colloidal gold , chemistry , cycloaddition , combinatorial chemistry , materials science , nuclear chemistry , nanotechnology , click chemistry , organic chemistry , catalysis

A novel bioorthogonal gold nanoparticle (AuNP) template displaying interfacial nitrone functional groups for bioorthogonal interfacial strain-promoted alkyne-nitrone cycloaddition reactions has been synthesized. These nitrone-AuNPs were characterized in detail using 1 H nuclear magnetic resonance spectroscopy, transmission electron microscopy, thermogravimetric analysis, and X-ray photoelectron spectroscopy, and a nanoparticle raw formula was calculated. The ability to control the conjugation of molecules of interest at the molecular level onto the nitrone-AuNP template allowed us to create a novel methodology for the synthesis of AuNP-based radiolabeled probes.

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