Open AccessK2S2O8-Mediated Hydroxyalkylation of Benzothiazoles with Alcohols in Aqueous Solution
Author(s) -
Wenxiu Xu,
Xiaoqiang Dai,
JianQuan Weng
Publication year - 2019
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.9b01695
Subject(s) - aqueous solution , chemistry , benzimidazole , ether , aqueous medium , organic chemistry , combinatorial chemistry , medicinal chemistry
The K 2 S 2 O 8 -mediated hydroxyalkylation of 2 H -benzothiazoles with aliphatic alcohols in aqueous solution was described. The mild and convenient protocol generated a series of hydroxyalkylated benzothiazoles in moderate to good yields. Besides, benzimidazole and ethers were also compatible in this reaction, leading to corresponding C2 ether-substituted heteroarenes.
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