Iodine-Mediated Oxidative Rearrangement of α,β-Unsaturated Diaryl Ketones: A Facile Access to 1,2-Diaryl Diketones | Zendy

Ajay H. Bansode | Zendy; Gurunath Suryavanshi | Zendy

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Iodine-Mediated Oxidative Rearrangement of α,β-Unsaturated Diaryl Ketones: A Facile Access to 1,2-Diaryl Diketones

Author(s) -

Ajay H. Bansode,

Gurunath Suryavanshi

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b00833

Subject(s) - iodine , chemistry , oxidative cleavage , oxidative phosphorylation , aryl , bond cleavage , combinatorial chemistry , molecule , medicinal chemistry , organic chemistry , catalysis , alkyl , biochemistry

A metal-free oxidative rearrangement was explored for the synthesis of 1,2-diaryl diketones by utilizing α,β-unsaturated diaryl ketones and I 2 /TBHP in good to high yields. The reaction proceeds via oxidative aryl migration, followed by C-C bond cleavage. A simple and high-yielding protocol was developed for the synthesis of a wide range of 1,2-diaryl diketones, which are the backbone for a variety of medicinally important molecules.

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