Open AccessCu-Doped Carbon Dots as Catalysts for the Chemiluminescence Detection of Glucose
Author(s) -
Yan Duan,
Yijun Huang,
Shengyu Chen,
Wei Zuo,
Bingfang Shi
Publication year - 2019
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.9b00738
Subject(s) - detection limit , chemiluminescence , citric acid , horseradish peroxidase , catalysis , carbon fibers , dopant , doping , chemistry , nuclear chemistry , materials science , inorganic chemistry , chromatography , organic chemistry , composite number , optoelectronics , enzyme , composite material
Development of metal-doped carbon dots (CDs) to effectively modulate their electronic properties and surface chemical reactivities is still in its early stage. In this paper, a facile solid-phase synthesis strategy was developed to synthesize Cu-doped CDs (Cu-CDs) using citric acid as the carbon source and Cu(NO 3 ) 2 ·3H 2 O as the dopant, respectively. The as-prepared Cu-CDs exhibited superior peroxidase-like activity to horseradish peroxidase and were stable under a wide range of pH and temperatures. Consequently, the Cu-CD-based chemiluminescence sensing was applied to sensitively detect glucose with a low detection limit of 0.32 μM, and the recoveries and the relative standard deviation of the serum sample are 87.2-112.2 and 8.16% ( n = 6), respectively. Notably, the proposed chemiluminescence sensing was also successfully applied for label-free detection of glucose in complex biological samples, which envisioned its potential applications in clinical diagnosis and other analytical assays.