Open AccessBCl3-Mediated C–N, C–S, and C–O Bond Formation of Imidazo[1,2-a]pyridine Benzylic Ethers
Author(s) -
Davinder Singh,
G. Ravi Kumar,
Divya Dheer,
Jyoti,
Manoj Kushwaha,
Qazi Naveed Ahmed,
Ravi Shankar
Publication year - 2019
Publication title -
acs omega
Language(s) - English
Resource type - Journals
ISSN - 2470-1343
DOI - 10.1021/acsomega.9b00035
Subject(s) - pyridine , chemistry , nucleophile , alkoxy group , medicinal chemistry , thio , stereochemistry , organic chemistry , catalysis , alkyl
An efficient BCl 3 -mediated reaction of imidazo[1,2- a ]pyridines has been developed for the C-N, C-S, and C-O bond formation. The salient features of this method correspond to the substitution of different nucleophiles via in situ unconventional debenzylation. The developed process is applicable for the synthesis of a wide variety of ((3-amino/thio/alkoxy)-methyl)-imidazo[1,2- a ]pyridines.
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