Base-Catalyzed 1,6-Conjugate Addition of Nitroalkanes to p-Quinone Methides under Continuous Flow | Zendy

Rajat Pandey | Zendy; Ramasamy Vijaya Anand | Zendy

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Base-Catalyzed 1,6-Conjugate Addition of Nitroalkanes to p-Quinone Methides under Continuous Flow

Author(s) -

Rajat Pandey,

Ramasamy Vijaya Anand

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b01971

Subject(s) - conjugate , base (topology) , continuous flow , quinone , catalysis , transformation (genetics) , chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , mathematics , physics , biochemistry , mathematical analysis , mechanics , gene

A mild base-catalyzed protocol for the synthesis of substituted nitroalkane derivatives has been developed under continuous flow using a microreaction technique. This transformation basically involves the 1,6-conjugate addition of nitroalkanes to p -quinone methides, leading to the substituted nitroalkanes in good to excellent yields.

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