Synthesis of 1,2,4-Trisubstituted-(1H)-imidazoles through Cu(OTf)2-/I2-Catalyzed C–C Bond Cleavage of Chalcones and Benzylamines | Zendy

C. T. Fathimath Salfeena | Zendy; Renjitha Jalaja | Zendy; R. K. Davis | Zendy; Eringathodi Suresh | Zendy; Sasidhar B. Somappa | Zendy

Open Access

Synthesis of 1,2,4-Trisubstituted-(1H)-imidazoles through Cu(OTf)₂-/I₂-Catalyzed C–C Bond Cleavage of Chalcones and Benzylamines

Author(s) -

C. T. Fathimath Salfeena,

Renjitha Jalaja,

R. K. Davis,

Eringathodi Suresh,

Sasidhar B. Somappa

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b01017

Subject(s) - chemistry , catalysis , bond cleavage , cleavage (geology) , yield (engineering) , aryl , medicinal chemistry , stereochemistry , organic chemistry , fracture (geology) , engineering , materials science , alkyl , geotechnical engineering , metallurgy

1,2,4-Trisubstituted-(1 H )-imidazoles have been synthesized by the Cu(OTf) 2 - and I 2 -catalyzed unusual C-C bond cleavage of chalcones and benzylamines. After the α,β-unsaturated C-C bond cleavage, the β-portion is eliminated from the reaction. Various aryl- and heteroaryl-substituted chalcones and benzylamines were well tolerated in this unusual transformation to yield the trisubstituted-(1 H )-imidazoles.

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