Xylopidimers A–E, Five New Guaiane Dimers with Various Carbon Skeletons from the Roots of Xylopia vielana | Zendy

Yi-Gong Guo | Zendy; Yang-Guo Xie | Zendy; Guo-Jing Wu | Zendy; Tao-Fang Cheng | Zendy; Shenglan Zhu | Zendy; ShiKai Yan | Zendy; HuiZi Jin | Zendy; Weidong Zhang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Xylopidimers A–E, Five New Guaiane Dimers with Various Carbon Skeletons from the Roots of Xylopia vielana

Author(s) -

Yi-Gong Guo,

Yang-Guo Xie,

Guo-Jing Wu,

Tao-Fang Cheng,

Shenglan Zhu,

ShiKai Yan,

HuiZi Jin,

Weidong Zhang

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b00828

Subject(s) - chemistry , nitric oxide , stereochemistry , ic50 , carbon fibers , single crystal , crystallography , organic chemistry , materials science , in vitro , biochemistry , composite number , composite material

Five new guaiane dimers, xylopidimers A-E ( 1-5 ), were isolated and identified from the roots of Xylopia vielana . The structures of 1-5 were elucidated by spectroscopic analysis and further confirmed by single-crystal X-ray diffraction. On the basis of the results of single-crystal X-ray analysis, 1-5 showed different carbon skeletons. Among these compounds, the unique connecting patterns of 1 and 2 caused significant differences on their carbon skeletons, which have not been reported. Moreover, 3-5 were also three new guaiane dimers. Among these compounds, 4 exhibited potent inhibitory activity against the production of nitric oxide with an IC 50 value of 4.59 μM in RAW264.7 cells stimulated by lipopolysaccharide.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research