English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In this paper, we report a direct and quantitative analytical method of small-biomolecule recognition with a molecularly imprinted polymer (MIP) interface, taking advantage of the potentiometric principle of a field-effect transistor (FET) sensor, which enables the direct detection of ionic charges without using labeling materials such as fluorescent dyes. The interaction of low-molecular-weight oligosaccharides such as paromomycin and kanamycin with the MIP interface including phenylboronic acid (PBA) was directly and quantitatively analyzed from the electrical signals of an MIP-coated FET sensor. In particular, the change in the potential response of the FET sensor was derived on the basis of the multi-Langmuir adsorption isotherm equations, considering the change in the molecular charges of PBA caused by the adsorption equilibrium of the analytes with the vinyl PBA-copolymerized MIP membrane. Thus, the potentiometric adsorption isotherm analysis can elucidate the formation of selective binding sites at the MIP interface. The electrochemical analysis of the functional biointerface used in this study supports the design and construction of sensors for small biomarkers.

Potentiometric Adsorption Isotherm Analysis of a Molecularly Imprinted Polymer Interface for Small-Biomolecule Recognition