Environment-Friendly Protocol for the Chlorination of Imidazoheterocycles by Chloramine-T | Zendy

Amrita Dey | Zendy; Mukta Singsardar | Zendy; Rajib Sarkar | Zendy; Alakananda Hajra | Zendy

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Environment-Friendly Protocol for the Chlorination of Imidazoheterocycles by Chloramine-T

Author(s) -

Amrita Dey,

Mukta Singsardar,

Rajib Sarkar,

Alakananda Hajra

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b01844

Subject(s) - reagent , environmentally friendly , thiazole , chemistry , combinatorial chemistry , solvent , green chemistry , reaction conditions , protocol (science) , organic chemistry , catalysis , reaction mechanism , medicine , ecology , alternative medicine , pathology , biology

An environment-friendly method for the chlorination of imidazoheterocycles has been developed using chloramine-T, a novel chlorinating reagent. A bunch of C-3 chloro-substituted imidazo[1,2- a ]pyridines with variety of functionalities have been synthesized in good yields under neat condition at room temperature within very short time. This chlorination process is also applicable to imidazo[2,1- b ]thiazole scaffolds. The present methodology is relevant to gram-scale synthesis. The major advantages of this system such as wide applicability, easy availability of reactants, open-air and metal- and solvent-free reaction conditions, no need of work-up, and simple purification technique represent a green synthetic protocol.

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