Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist | Zendy

Su-Jeong Lee | Zendy; Mallesham Samala | Zendy; Seo Yeon Woo | Zendy; Dongyup Hahn | Zendy; Dayoung Kim | Zendy; Tara Man Kadayat | Zendy; Kyungjin Jung | Zendy; Jina Kim | Zendy; DongSu Kim | Zendy; Sugyeong Kwon | Zendy; Shinae Kim | Zendy; KyungHee Kim | Zendy; SangJip Nam | Zendy; Sung Jin Cho | Zendy; Jungwook Chin | Zendy

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Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist

Author(s) -

Su-Jeong Lee,

Mallesham Samala,

Seo Yeon Woo,

Dongyup Hahn,

Dayoung Kim,

Tara Man Kadayat,

Kyungjin Jung,

Jina Kim,

DongSu Kim,

Sugyeong Kwon,

Shinae Kim,

KyungHee Kim,

SangJip Nam,

Sung Jin Cho,

Jungwook Chin

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b01689

Subject(s) - enantioselective synthesis , thiazoline , agonist , chemistry , peroxisome proliferator activated receptor , metabolite , receptor , stereochemistry , threonine , peroxisome , biochemistry , biology , serine , phosphorylation , catalysis

The convergent and enantioselective synthesis of a highly potent human peroxisome proliferator-activated receptor delta agonist is presented. More specifically, the thiazoline structure, which constitutes the biosynthetically distinctive core structure of pulicatin (a secondary metabolite of symbiotic bacteria), was synthesized from a commercially available and inexpensive chiral pool of l-threonine.

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