Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones | Zendy

Zhiguo Zhang | Zendy; Xiaolong Gao | Zendy; Yameng Wan | Zendy; Yuanyuan Huang | Zendy; Guoqing Huang | Zendy; Guisheng Zhang | Zendy

Open Access

Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones

Author(s) -

Zhiguo Zhang,

Xiaolong Gao,

Yameng Wan,

Yuanyuan Huang,

Guoqing Huang,

Guisheng Zhang

Publication year - 2017

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b00626

Subject(s) - ammonium acetate , tandem , chemistry , aldol condensation , intermolecular force , ethylene glycol , aldol reaction , cascade reaction , condensation reaction , organic chemistry , one pot synthesis , condensation , solvent , medicinal chemistry , catalysis , molecule , high performance liquid chromatography , materials science , physics , composite material , thermodynamics

An efficient tandem intermolecular one-pot aldol condensation/aza-addition reaction of 2-methyl-3-carbamoylpyrroles and aldehydes was developed for the synthesis of 2,3,6,7-tetrahydro-1 H -pyrrolo[3,2- c ]pyridin-4(5 H )-ones. The reaction proceeded using only 3.0 equiv of ammonium acetate promoter in green solvent poly(ethylene glycol)-400 at 100 °C to afford a series of pyrrolo[3,2- c ]pyridinone derivatives in good to excellent yields.

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