Modifier-Free Microfluidic Electrochemical Sensor for Heavy-Metal Detection

Heavy-metal pollution poses severe threat to ecological systems and presents a great challenge for global sustainability. Portable point-of-care sensing platform for detection/monitoring of heavy-metal pollution in the environment is urgently demanded. Herein, a highly sensitive, robust, and low-cost microfluidic electrochemical carbon-based sensor (μCS) for detection of trace heavy metals is presented. The miniaturized μCS devices are based on a microfluidic paper channel combined with a novel three-dimensional layout with working and counter electrodes facing each other and analyte flowing along the microfluidic channel between these two electrodes. Pristine graphite foil free of any surface modifier is not only used as the electronically conductive pad but also directly employed as the working electrode for fabricating the μCS. The resulting simple and portable device was applied in Cd 2+ and Pb 2+ detection using square-wave anodic stripping voltammetry. Detection limits down to 1.2 μg/L for Cd 2+ and 1.8 μg/L for Pb 2+ can be achieved over the μCS. The μCS devices are also found to be highly robust, and 10 repetitive measurements with a single μCS device resulted to be highly reproducible.