BBB: Permeable Conjugate of Exogenic GABA | Zendy

Qian Li | Zendy; Shuhao Wang | Zendy; Weibin Xiao | Zendy; Chunqian Huang | Zendy; Hua Li | Zendy; Manji Sun | Zendy

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BBB: Permeable Conjugate of Exogenic GABA

Author(s) -

Qian Li,

Shuhao Wang,

Weibin Xiao,

Chunqian Huang,

Hua Li,

Manji Sun

Publication year - 2017

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b00425

Subject(s) - glutamate receptor , neurotransmitter , inhibitory postsynaptic potential , conjugate , chemistry , excitatory postsynaptic potential , glutamic acid , neuroscience , pharmacology , blood–brain barrier , amino acid , central nervous system , biochemistry , biology , receptor , mathematical analysis , mathematics

Neurotransmitters are the key factors in ameliorating the symptoms of nervous system diseases. Stroke/cerebral ischemia has been proven to be caused by the excess release of excitatory amino acid glutamate in the brain, and the inhibitory neurotransmitter γ-aminobutyric acid (GABA) is considered to be the best choice to counteract the action of glutamate. Here, we show that GABA conjugated to a cytoplasmic transduction peptide (YGRRA) by means of custom chemical synthesis could penetrate through the blood-brain barrier, increasing the GABA level in the plasma of rats and mice, which, as a result, display a state of calmness and somnolence.

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