N-Methyl-β-carbolinium Salts and an N-Methylated 8-Oxoisoguanine as Acetylcholinesterase Inhibitors from a Solitary Ascidian, Cnemidocarpa irene | Zendy

Yohei Tadokoro | Zendy; Teruaki Nishikawa | Zendy; Taichi Ichimori | Zendy; Satoko Matsunaga | Zendy; Masaki Fujita | Zendy; Ryuichi Sakai | Zendy

Open Access

N-Methyl-β-carbolinium Salts and an N-Methylated 8-Oxoisoguanine as Acetylcholinesterase Inhibitors from a Solitary Ascidian, Cnemidocarpa irene

Author(s) -

Yohei Tadokoro,

Teruaki Nishikawa,

Taichi Ichimori,

Satoko Matsunaga,

Masaki Fujita,

Ryuichi Sakai

Publication year - 2017

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b00127

Subject(s) - tunicate , acetylcholinesterase , aché , stereochemistry , chemistry , derivative (finance) , acetylcholinesterase inhibitor , fluorescence , enzyme , biochemistry , biology , ecology , physics , quantum mechanics , economics , financial economics

New brominated β-carbolines irenecarbolines A ( 1 ) and B ( 4 ) along with known β-carbolines 2 and 3 and a new 8-oxoisoguanine derivative, 5 , were isolated from a solitary ascidian, Cnemidocarpa irene . The structures of these compounds were determined on the basis of their spectral data. All, except for 3 , inhibited the action of acetylcholinesterase (AchE). The activities of 1 and 5 were comparable to those of galantamine, a clinically used AchE inhibitor. Compounds 1 and 2 were found to be present in high concentrations in blood, and fluorescence was observed in certain types of cells found in the blood of the tunicate.

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