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New brominated β-carbolines irenecarbolines A ( 1 ) and B ( 4 ) along with known β-carbolines 2 and 3 and a new 8-oxoisoguanine derivative, 5 , were isolated from a solitary ascidian, Cnemidocarpa irene . The structures of these compounds were determined on the basis of their spectral data. All, except for 3 , inhibited the action of acetylcholinesterase (AchE). The activities of 1 and 5 were comparable to those of galantamine, a clinically used AchE inhibitor. Compounds 1 and 2 were found to be present in high concentrations in blood, and fluorescence was observed in certain types of cells found in the blood of the tunicate.

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N-Methyl-β-carbolinium Salts and an N-Methylated 8-Oxoisoguanine as Acetylcholinesterase Inhibitors from a Solitary Ascidian, Cnemidocarpa irene