English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Development of biosensors with high sensitivity, high spatial resolution, and low cost has received significant attention for their applications in medical diagnosis, diabetes management, and environment-monitoring. However, achieving a direct electrical contact between redox enzymes and electrode surfaces and enhancing the operational stability still remain as challenges. Inorganic metal nanocrystals (NCs) with precisely controlled shape and surface structure engineered with an appropriate organic coating can help overcome the challenges associated with their stability and aggregation for practical biosensor applications. Herein, we describe a facile, room-temperature, seed-mediated solution-phase route to synthesize monodisperse Pd@Pt core-shell nanocubes with subnanometer-thick platinum (Pt) shells. The enzyme electrode consisting of Pd@Pt core-shell NCs was first covered with a chitosan (CS) polymer and then glucose oxidase (GOx) immobilized by a covalent linkage to the CS. This polymer permits covalent immobilization through active amino (-NH) side groups to improve the stability and preserve the biocatalytic functions while the Pd@Pt NCs facilitate enhanced direct electron transfer (DET) in the biosensor. The resultant biosensor promotes DET and exhibits excellent performance for the detection of glucose, with a sensitivity of 6.82 μA cm -2 mM -1 and a wide linear range of 1-6 mM. Our results demonstrate that sensitive electrochemical glucose detection based on Pd@Pt core-shell NCs provides remarkable opportunities for designing low-cost and sensitive biosensors.

Chitosan-Covered Pd@Pt Core–Shell Nanocubes for Direct Electron Transfer in Electrochemical Enzymatic Glucose Biosensor