Open AccessBalanced Effects of Surface Reactivity and Self-Association of Bifunctional Polyaspartamide on Stem Cell Adhesion
Author(s) -
Jooyeon Park,
Yijiang Yu,
Joyeon Kim,
Ellen C. Qin,
MyungJoo Kim,
Eunkyung Ko,
Hyunjoon Kong
Publication year - 2017
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.6b00563
Subject(s) - wetting , bifunctional , materials science , surface modification , polymer , adhesion , nanotechnology , chemical engineering , chemistry , polymer chemistry , composite material , organic chemistry , engineering , catalysis
Extensive efforts have been made to regulate surface wettability using bivalent polymers composed of hydrophobic surface-reactive groups and hydrophilic groups. To further enhance the controllability, this study demonstrates that the balance between the surface reactivity and self-aggregation of bivalent poly(hydroxyethyl- co -methacryloxyethyl aspartamide) (PHMAA) is crucial in controlling the wettability of methacrylated glass and thus the adhesion of stem cells. In particular, the wettability of the glass and the subsequent cell spreading became maximal with PHMAA that led to the largest and most uniform coverage of hydroxyl groups. In summary, this study would be useful in advancing various molecules used for surface engineering.