Open AccessOxidation-Responsive, EuII/III-Based, Multimodal Contrast Agent for Magnetic Resonance and Photoacoustic Imaging
Author(s) -
Lina A. Basal,
Yan Yan,
Yimin Shen,
E. Mark Haacke,
Mohammad Mehrmohammadi,
Matthew J. Allen
Publication year - 2017
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.6b00514
Subject(s) - magnetic resonance imaging , nuclear magnetic resonance , photoacoustic imaging in biomedicine , contrast (vision) , resonance (particle physics) , chemistry , materials science , physics , optics , atomic physics , radiology , medicine
We report, for the first time, a multimodal, oxidation-responsive contrast agent for magnetic resonance imaging and photoacoustic imaging that uses the differences in the properties between Eu in the +2 and +3 oxidation states. The enhancement of contrast in T 1 -weighted magnetic resonance and photoacoustic imaging was observed in the +2 but not in the +3 oxidation state, and the complex is a known chemical exchange saturation transfer agent for magnetic resonance imaging in the +3 oxidation state.