Open AccessFolate Receptor-Targeted Theranostic Nanoconstruct for Surface-Enhanced Raman Scattering Imaging and Photodynamic Therapy
Author(s) -
Andrew M. Fales,
Bridget M. Crawford,
Tuan VoDinh
Publication year - 2016
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.6b00176
Subject(s) - photodynamic therapy , folate receptor , raman scattering , cancer research , materials science , medicine , targeted therapy , cancer cell , cancer , raman spectroscopy , nanotechnology , biophysics , chemistry , optics , biology , physics , organic chemistry
We report the synthesis of a folate receptor (FR)-targeted theranostic nanocomposite for surface-enhanced Raman scattering (SERS) imaging and photodynamic therapy (PDT). FR-specific SERS detection and PDT are demonstrated in vitro using two FR-positive cancer cell lines and one FR-negative cancer cell lines.