Design of a Sensitive Fluorescent Zn-Based Metal–Organic Framework Sensor for Cimetidine Monitoring in Biological and Pharmaceutical Samples | Zendy

Zahra Afravi | Zendy; Valiollah Nobakht | Zendy; Nahid Pourreza | Zendy; Matineh Ghomi | Zendy; Damian Trzybiński | Zendy; Krzysztof Woźniak | Zendy

Open Access

Design of a Sensitive Fluorescent Zn-Based Metal–Organic Framework Sensor for Cimetidine Monitoring in Biological and Pharmaceutical Samples

Author(s) -

Zahra Afravi,

Valiollah Nobakht,

Nahid Pourreza,

Matineh Ghomi,

Damian Trzybiński,

Krzysztof Woźniak

Publication year - 2022

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.2c00874

Subject(s) - pyromellitic dianhydride , fourier transform infrared spectroscopy , fluorescence , thermogravimetric analysis , powder diffraction , dynamic light scattering , solvent , materials science , zinc , infrared spectroscopy , metal organic framework , chemistry , analytical chemistry (journal) , nuclear chemistry , crystallography , chemical engineering , organic chemistry , nanotechnology , nanoparticle , polyimide , physics , layer (electronics) , quantum mechanics , adsorption , engineering

A new highly fluorescent zinc-organic framework [Zn 2 (btca)(DMSO) 2 ] n ( Zn-MOF ) was prepared via in situ ligand formation by the solvothermal reaction of Zn(NO 3 ) 2 ·6H 2 O and pyromellitic dianhydride (PMDA) in DMSO solvent. During the solvothermal reaction, PMDA was gradually hydrolyzed to a pyromellitic acid, 1,2,4,5-benzene tetracarboxylic acid (H 4 btca), to provide a tetracarboxylic acid as a linker in the reaction medium. Single-crystal X-ray diffraction analysis exhibits a 3D porous structure with open tetragonal channels running along the crystallographic c -axis. The Zn-MOF was explored as an on-mode fluorescent sensor for tracing cimetidine in biological fluids and pharmaceutical samples in the presence of interfering species. The results show a quick response in a short time range. The characteristics of this sensor were investigated by field-emission scanning electron microscopy, dynamic light scattering, energy-dispersive X-ray analysis, powder X-ray diffraction, Fourier transform infrared and UV-vis spectroscopy as well as thermogravimetric, and elemental analyses.

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