Open AccessSupramolecular Self-Assembly Mediated by Multiple Hydrogen Bonds and the Importance of C–S···N Chalcogen Bonds in N′-(Adamantan-2-ylidene)hydrazide Derivatives
Author(s) -
Lamya H. Al-Wahaibi,
Karthick Vishal Asokan,
Nora Hamad Al-Shaalan,
Samar S. Tawfik,
Hanan M. Hassan,
Ali A. El-Emam,
M. Judith Percino,
Subbiah Thamotharan
Publication year - 2022
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.2c00159
Subject(s) - chemistry , intramolecular force , hydrogen bond , intermolecular force , crystallography , density functional theory , hydrazide , molecule , lone pair , crystal structure , supramolecular chemistry , chalcogen , stereochemistry , computational chemistry , organic chemistry
The present article comprehensively examines six N '-(adamantan-2-ylidene)hydrazide derivatives using the Hirshfeld surface analysis, PIXEL energy for molecular dimers, lattice energies for crystal packing, and topological analysis for intramolecular and intermolecular interactions. The crystal structure of one of the N '-(adamantan-2-ylidene)hydrazide derivatives, namely, N '-(adamantan-2-ylidene)-5-bromothiophene-2-carbohydrazide 1 , C 15 H 17 N 2 OSBr, has been determined and analyzed in detail along with five closely related structures. The molecular conformation of 1 is locked by an intramolecular C-S···N chalcogen bond as found in one of its closely related structure, namely, N '-(adamantan-2-ylidene)thiophene-2-carbohydrazide. Furthermore, a detailed potential energy surface scan analysis has been performed to highlight the importance of a chalcogen bond. Two of these compounds possess syn-orientation for amide units, whereas the corresponding moiety exhibits anti-conformations in the remaining four structures. The Hirshfeld surface and its decomposed fingerprint plots provide a qualitative picture of acyl substituent effects on the intermolecular interactions toward crystal packing of these six structures. Intermolecular interaction energies for dimers observed in these structures calculated by density functional theory (B97D3/def2-TZVP) and PIXEL (MP2/6-31G**) methods are comparable. This study also identifies that multiple hydrogen bonds, including N/C-H···O/N and C-H···π interactions, are collectively responsible for a self-assembled synthon. The nature and strength of these interactions have been studied using atoms in molecule topological analysis. The in vitro antiproliferative activity of compound 1 was assessed against five human tumor cell lines and showed marked antiproliferative activity.