Open AccessEnhancement of Curcuma xanthorrhiza Roxb Phytochemical Dissolution via Micronization Using a Supercritical Antisolvent Technique
Author(s) -
Siti Machmudah,
Rizky Prasetya Mahardika,
Syahna Almadilla,
Sugeng Winardi,
Wahyu Diono,
Hideki Kanda,
Motonobu Goto
Publication year - 2022
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c06911
Subject(s) - micronization , rhizome , polyvinylpyrrolidone , supercritical carbon dioxide , supercritical fluid , dissolution , chemistry , zingiberaceae , aqueous solution , chromatography , particle size , acetone , materials science , traditional medicine , organic chemistry , medicine
Fine particles comprising Curcuma xanthorrhiza Roxb ( C. xanthorrhiza ) rhizome extract were successfully generated using a supercritical carbon dioxide (SCCO 2 ) antisolvent technique. The SCCO 2 antisolvent process was performed at 40 °C with 8-16 MPa operating pressures. The CO 2 and feed solution flow rates were 15 and 0.25 mL min -1 , respectively. The mixture of C. xanthorrhiza rhizome extract and a polyvinylpyrrolidone (PVP) polymer in acetone-ethanol was used as a feed solution. The collected particle products seemed to possess spherical and spherical-like morphologies with a diameter of less than 500 nm. The infrared spectroscopy analysis showed that the structural properties of C. xanthorrhiza rhizome extract did not change after treatment with the SCCO 2 antisolvent. Furthermore, the addition of the PVP polymer in the C. xanthorrhiza rhizome extract particle products may improve their dissolution significantly in an aqueous solution medium.