Open AccessExtraction of Functional Components from Freeze-Dried Angelica furcijuga Leaves Using Supercritical Carbon Dioxide
Author(s) -
Yuriko Hoshino,
Wahyu Diono,
Siti Machmudah,
Shoji Hirayama,
Hideki Kanda,
Munehiro Hoshino,
Motonobu Goto
Publication year - 2022
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c06105
Subject(s) - supercritical carbon dioxide , ferulic acid , extraction (chemistry) , chromatography , chemistry , carbon dioxide , solubility , supercritical fluid extraction , supercritical fluid , ethanol , organic chemistry
Angelica furcijuga ( A. furcijuga ), as a material for traditional Chinese medicine, has been widely used in Asian countries, such as China, Korea, and Japan, for several centuries owing to its therapeutic effects. In this study, A. furcijuga leaves were used as starting materials to extract functional substances using supercritical carbon dioxide (SC-CO 2 ) at pressure and temperature ranges of 20-40 MPa and 40-80 °C, respectively. The extraction process was performed in a semibatch-type system with extraction times of 15-120 min. The high-performance liquid chromatography analysis indicated that kaempferol, ferulic acid, ligustilide, and butylidenephthalide as selected functional substances were successfully extracted under these operating conditions. An operating pressure of 30 MPa with an extraction time of 60 min seems to be an appropriate pressure to extract functional components from A. furcijuga leaves. The Hansen solubility parameter values and statistical analysis showed that SC-CO 2 with 10% ethanol addition is a feasible tool to isolate these selected functional substances from the A. furcijuga matrix.