Open AccessElectrochemical [4 + 1] Tandem sp3(C–H) Double Amination for the Direct Synthesis of 3-Acyl-Functionalized Imidazo[1,5-a]pyridines
Author(s) -
Qiang Wang,
Xin Yao,
Xianjing Xu,
Shuai Zhang,
Lei Ren
Publication year - 2022
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c06029
Subject(s) - ammonium iodide , amination , chemistry , tandem , electrochemistry , pyridine , iodide , ammonium , combinatorial chemistry , reductive amination , medicinal chemistry , organic chemistry , catalysis , electrode , materials science , composite material
3-Acyl imidazo[1,5- a ]pyridines, featured pharmaceutical moieties that were prepared by a three-step reaction conventionally, could be obtained in one step by an electrochemical tandem sp 3 (C-H) double amination of acetophenones with pyridine ethylamines using ammonium iodide as a redox mediator.