Open AccessElectron Transfer-Mediated Photodegradation of Phototoxic Antipsychotic Drug Quetiapine
Author(s) -
Anamika Gupta,
Amit Kumar,
Mohd. Rehan Zaheer,
Roohi Roohi,
Sajid Iqbal,
Jawaid Iqbal
Publication year - 2021
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c05302
Subject(s) - photochemistry , chemistry , electron acceptor , photodegradation , phototoxicity , electron donor , quetiapine , electron transfer , photocatalysis , catalysis , organic chemistry , biochemistry , schizophrenia (object oriented programming) , computer science , in vitro , programming language
Quetiapine (QTP) ( 1 ), a psychotropic agent belonging to a chemical class, dibenzothiazepine derivatives, is photosensitive and photolabile. Its photochemistry was studied in the presence of an electron donor N , N -dimethylaniline (DMA) and an electron acceptor 1,4-dicyanobenzene (DCB) under anaerobic conditions. This resulted in photoinduced electron transfer-mediated transformation of drug QTP. Irradiation of Quetiapine (QTP, 1 ) in the presence of electron donor N , N -dimethylaniline (DMA) under anaerobic conditions in a photochemical reactor afforded one major photoproduct 2 when irradiation of QTP ( 1 ) was carried out in the presence of electron acceptor 1,4-dicyanobenzene (DCB) under similar conditions; it afforded 3 as a major photoproduct. These photoproducts were isolated and characterized on the basis of their spectral (IR, UV, 1 H NMR, 13 C NMR, and mass spectra) studies. The photophysical properties of Quetiapine were also determined in several solvents to investigate the relevance of the molecular structure in their photophysics and consequently in their photochemistry.