Open AccessAmphiphilic Diketopyrrolopyrrole Derivatives for Efficient Near-Infrared Fluorescence Imaging and Photothermal Therapy
Author(s) -
Xiuli Zheng,
Shuaishuai Bian,
Weimin Liu,
Chuangli Zhang,
Jiasheng Wu,
Haohui Ren,
Wenjun Zhang,
ChunSing Lee,
Pengfei Wang
Publication year - 2021
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c03947
Subject(s) - photothermal therapy , amphiphile , ethylene glycol , biocompatibility , fluorescence , fluorescence lifetime imaging microscopy , materials science , nanotechnology , nanoparticle , combinatorial chemistry , chemistry , organic chemistry , copolymer , polymer , physics , quantum mechanics , composite material , metallurgy
The design and synthesis of single-molecule amphiphilic and multifunctional phototherapeutic agents are important to cancer diagnosis and therapy. In this work, we developed three amphiphilic diketopyrrolopyrrole derivatives (TPADPP, DTPADPP, and TPADDPP) with different donor-acceptor structures and poly(ethylene glycol) side chains. The corresponding nanoparticles (NPs) were obtained via a self-assembly from three amphiphilic DPP derivatives and used as smart phototherapeutic agents for tumor diagnosis and treatment. The three amphiphilic DPP NPs exhibited near-infrared (NIR) emissions and good biocompatibility. Thus, they could be used as fluorescence (FL) imaging agents for guided therapy. DTPADPP NPs and TPADDPP NPs also displayed excellent photothermal performance and high accumulation in the tumor. Owing to these beneficial features, the DTPADPP NPs and TPADDPP NPs synthesized herein are suitable for NIR FL imaging and effective photothermal therapy against the tumor in vivo .