Open AccessMechanisms and Molecular Targets of Compound Danshen Dropping Pill for Heart Disease Caused by High Altitude Based on Network Pharmacology and Molecular Docking
Author(s) -
Jiayi Yan,
P. Ruan,
Yunxuan Ge,
Jing Gao,
Hongling Tan,
Cheng-Rong Xiao,
Quansheng Gao,
Zhuo Zhang,
Yue Gao
Publication year - 2021
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c03282
Subject(s) - pharmacology , docking (animal) , traditional chinese medicine , medicine , pill , pi3k/akt/mtor pathway , computational biology , traditional medicine , chemistry , biology , signal transduction , biochemistry , alternative medicine , nursing , pathology
Compound Danshen dropping pill (CDDP), a famous Chinese medicine formula, has been widely used to treat high-altitude heart disease in China. However, its molecular mechanisms, potential targets, and bioactive ingredients remain elusive. In this study, network pharmacology, molecular docking, and validation experiments were combined to investigate the effective active ingredients and molecular mechanisms of CDDP in the treatment of high-altitude heart disease. Tan IIA may be the main active component of CDDP in the treatment of high-altitude heart disease via HIF-1/PI3K/Akt pathways.