Open AccessUltrasound-Assisted Iodination of Imidazo[1,2-α]pyridines Via C–H Functionalization Mediated by tert-Butyl Hydroperoxide
Author(s) -
Hua Yang,
Ning Huang,
Nengqing Wang,
Haicheng Shen,
Fan Teng,
Xiaoying Li,
Hongmei Jiang,
Tan Mei-Chen
Publication year - 2021
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c02645
Subject(s) - halogenation , atom economy , regioselectivity , catalysis , chemistry , substrate (aquarium) , iodine , environmentally friendly , surface modification , ultrasound , solvent , combinatorial chemistry , alcohol , green chemistry , nuclear chemistry , medicinal chemistry , organic chemistry , reaction mechanism , ecology , oceanography , physics , acoustics , biology , geology
A novel metal catalyst-free and environmentally friendly method for the regioselective iodination of imidazo[1,2-α]pyridines at their C3 position is disclosed, which has a wide substrate scope and could be sustainable. This reaction proceeds through ultrasound acceleration in the presence of a green alcohol solvent. Compared with a conventional heating system, the reaction efficiency and the rate are significantly improved and the iodine atom economy is maximized using ultrasound techniques.