Open AccessSynthesis of 2-Aryl-4H-thiochromen-4-one Derivatives via a Cross-Coupling Reaction
Author(s) -
Peng Li,
Shengnan Li,
Gang Li,
Huanwei Huang
Publication year - 2021
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c01778
Subject(s) - aryl , combinatorial chemistry , scope (computer science) , construct (python library) , coupling reaction , chemistry , ligand (biochemistry) , palladium , coupling (piping) , catalysis , organic chemistry , computer science , materials science , biochemistry , alkyl , receptor , metallurgy , programming language
A concise and efficient cross-coupling synthetic strategy has been developed to construct 2-aryl-4 H -thiochromen-4-one derivatives from 2-sulfinyl-thiochromones and arylboronic acids. This reaction proceeds via a catalyst system of Lewis acid and palladium(II) combined with XPhos as an optimal ligand in moderate to good yields. Besides, this flexible methodology provides a wide scope for the synthesis of different functionally substituted thiochromone scaffolds and can be further exploited to construct diverse thioflavone libraries for pharmaceutical research.