Open AccessRole and Mechanism of Exosome-Derived Long Noncoding RNA HOTAIR in Lung Cancer
Author(s) -
Lanlan Chen,
Shenhui Huang,
Jincheng Huang,
Qiujuan Chen,
Qihong Zhuang
Publication year - 2021
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.1c00905
Subject(s) - hotair , exosome , cancer research , a549 cell , microvesicles , metastasis , downregulation and upregulation , gene knockdown , long non coding rna , lung cancer , biology , tumor progression , microrna , cancer , medicine , cell culture , pathology , gene , biochemistry , genetics
HOX transcript antisense RNA (HOTAIR) is a long noncoding RNA (lncRNA) that promotes tumor growth and metastasis. Exosomes can mediate intracellular communication in cancer by transferring active molecules. However, the role and mechanism of HOTAIR in nonsmall cell lung cancer (NSCLC) are still unclear. This study mainly explores the role and mechanism of exosome-derived HOTAIR in NSCLC.