Open AccessCu(II)-Containing Metal–Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells
Author(s) -
Jian Luo,
Lv-Fang Ying,
Feng Zhang,
Ze Zhou,
Yanguo Zhang
Publication year - 2021
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.0c06270
Subject(s) - osteosarcoma , annexin , pyridine , apoptosis , chemistry , metal organic framework , catalysis , reactive oxygen species , metal , pi , solvent , cancer research , medicinal chemistry , biochemistry , organic chemistry , biology , adsorption
A novel metal-organic framework (MOF) has been produced via Cu(NO 3 ) 2 ·6H 2 O reaction with 3-(1 H -tetrazol-5-yl)pyridine (HL) in water, and its chemical formula is {[(Cu(L) 2 (H 2 O) 2 ](H 2 O) 8 ) n } ( 1 ). Due to its high density of coordinately unsaturated sites along with large one-dimensional (1D) hexagonal channels, the activated complex 1 ( 1a ) was explored as the solvent-free heterogeneous catalyst for cyanosilylation under mind conditions. The inhibitory function of compound 1a against the survival rate of OS-732 osteosarcoma cells was evaluated via Cell Counting Kit-8 (CCK-8) detection kit. Furthermore, the Annexin V-FITC/PI detection kit and the active oxygen (ROS) detection kit was carried out to determine the cell apoptosis levels and the ROS accumulation in OS-732 osteosarcoma cells after treatment by compound 1a .