Cu(II)-Containing Metal–Organic Framework with 1D Hexagonal Channels for Cyanosilylation Reaction and Anticancer Activity on Osteosarcoma Cells

A novel metal-organic framework (MOF) has been produced via Cu(NO 3 ) 2 ·6H 2 O reaction with 3-(1 H -tetrazol-5-yl)pyridine (HL) in water, and its chemical formula is {[(Cu(L) 2 (H 2 O) 2 ](H 2 O) 8 ) n } ( 1 ). Due to its high density of coordinately unsaturated sites along with large one-dimensional (1D) hexagonal channels, the activated complex 1 ( 1a ) was explored as the solvent-free heterogeneous catalyst for cyanosilylation under mind conditions. The inhibitory function of compound 1a against the survival rate of OS-732 osteosarcoma cells was evaluated via Cell Counting Kit-8 (CCK-8) detection kit. Furthermore, the Annexin V-FITC/PI detection kit and the active oxygen (ROS) detection kit was carried out to determine the cell apoptosis levels and the ROS accumulation in OS-732 osteosarcoma cells after treatment by compound 1a .