Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp3)-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium | Zendy

Zhenghong Zhou | Zendy; Kangfei Hu | Zendy; Jiawei Wang | Zendy; Zhibin Li | Zendy; Yan Zhang | Zendy; Zhenggen Zha | Zendy; Zhiyong Wang | Zendy

Open Access

Electrosynthesis of Quinazolines and Quinazolinones via an Anodic Direct Oxidation C(sp³)-H Amination/C-N Cleavage of Tertiary Amine in Aqueous Medium

Author(s) -

Zhenghong Zhou,

Kangfei Hu,

Jiawei Wang,

Zhibin Li,

Yan Zhang,

Zhenggen Zha,

Zhiyong Wang

Publication year - 2020

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.0c04865

Subject(s) - electrosynthesis , amination , amine gas treating , chemistry , cleavage (geology) , electrochemistry , aqueous solution , anode , aqueous medium , combinatorial chemistry , organic chemistry , catalysis , electrode , materials science , composite material , fracture (geology)

An electrochemical synthesis for quinazolines and quinazolinones was developed via a C(sp 3 )-H amination/C-N cleavage by virtue of the anodic oxidation. The reaction can be carried out in aqueous media under mild conditions to afford the desired products with high yields. The reaction mechanism was proposed after detailed investigation.

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