Synthesis of Chromeno[4,3-b]pyrrol-4(1H)-ones through a Multicomponent Reaction and Cyclization Strategy | Zendy

Xiangfeng Lai | Zendy; Chao Che | Zendy

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Synthesis of Chromeno[4,3-b]pyrrol-4(1H)-ones through a Multicomponent Reaction and Cyclization Strategy

Author(s) -

Xiangfeng Lai,

Chao Che

Publication year - 2020

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.0c03589

Subject(s) - yield (engineering) , scope (computer science) , intramolecular force , substrate (aquarium) , combinatorial chemistry , chemistry , reaction conditions , component (thermodynamics) , stereochemistry , computer science , organic chemistry , catalysis , materials science , physics , biology , ecology , thermodynamics , metallurgy , programming language

A novel three-component reaction of 2-oxo-2 H -chromene-3-carbaldehydes with isocyanides and anilines was developed for one-pot assembly of biologically intriguing chromeno[4,3- b ]pyrrol-4(1 H )-ones, which can also be transferred into diverse polycyclic fused scaffolds through further synthetic manipulations. The described method tolerates a broad substrate scope and proceeds in moderate to good yield via a sequential multicomponent reaction and intramolecular Michael cyclization.

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