Open AccessLaquinimod Prevents Adipogenesis and Obesity by Down-Regulating PPAR-γ and C/EBPα through Activating AMPK
Author(s) -
Guang Wang,
Bing Wu,
Lening Zhang,
Chen Yang,
Bo Zhang,
Heyuan Wang
Publication year - 2020
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.0c02525
Subject(s) - adipogenesis , oil red o , ampk , adipose tissue , sterol regulatory element binding protein , endocrinology , medicine , adipocyte , glucose transporter , glut4 , 3t3 l1 , chemistry , white adipose tissue , triglyceride , protein kinase a , biology , biochemistry , kinase , cholesterol , sterol , insulin
obesity is defined as excessive accumulation of adipose tissues and is becoming one of the main global severe public health issues. The present study aims to investigate the anti-adipogenesis of laquinimod and the underlying mechanism.