Open AccessCatalytic Nanoassemblies Formed by Short Peptides Promote Highly Enantioselective Transfer Hydrogenation
Author(s) -
Martin A. Dolan,
Prem N. Basa,
Oleksii Zozulia,
Zsofia LengyelZhand,
René Lebl,
Eric M. Kohn,
Sagar Bhattacharya,
Ivan V. Korendovych
Publication year - 2019
Publication title -
acs nano
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.554
H-Index - 382
eISSN - 1936-086X
pISSN - 1936-0851
DOI - 10.1021/acsnano.9b03880
Subject(s) - enantioselective synthesis , supramolecular chemistry , catalysis , nanotechnology , combinatorial chemistry , aqueous solution , chemistry , materials science , organic chemistry , molecule
Self-assembly enables formation of incredibly diverse supramolecular structures with practically important functions from simple and inexpensive building blocks. Here, we show how a semirational, bottom-up approach to create emerging properties can be extended to a design of highly enantioselective catalytic nanoassemblies. The designed peptides comprising as few as two amino acid residues spontaneously self-assemble in the presence of metal ions to form supramolecular, vesicle-like nanoassemblies that promote transfer hydrogenation of ketones in an aqueous phase with excellent conversion rates and enantioselectivities (>90% ee).