Open AccessControl of Intra- versus Extracellular Bioorthogonal Catalysis Using Surface-Engineered Nanozymes
Author(s) -
Rahul Das,
Ryan F. Landis,
Gülen Yesilbag Tonga,
Roberto CaoMilàn,
David C. Luther,
Vincent M. Rotello
Publication year - 2018
Publication title -
acs nano
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.554
H-Index - 382
eISSN - 1936-086X
pISSN - 1936-0851
DOI - 10.1021/acsnano.8b05370
Subject(s) - bioorthogonal chemistry , prodrug , nanotechnology , catalysis , nanoparticle , colloidal gold , surface engineering , surface modification , chemistry , materials science , combinatorial chemistry , click chemistry , biochemistry
Bioorthogonal transformation of prodrugs and profluorophores using transition metal catalysts (TMCs) offers a promising strategy for therapeutic and imaging applications. Here, we report the surface engineering of nanoparticles to specifically localize gold nanoparticles (AuNPs) with encapsulated TMCs (nanozymes) to either the inside or outside of cells. The ability to control nanozyme localization and hence activity was demonstrated by the activation of pro-fluorophores and prodrugs intra- and extracellularly, establishing the potential of engineered nanozyme platforms for both diagnostic and therapeutic purposes.