Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers | Zendy

Maria-Eleni Kyriazi | Zendy; Davide Giust | Zendy; Afaf H. ElSagheer | Zendy; Peter M. Lackie | Zendy; Otto L. Muskens | Zendy; Tom Brown | Zendy; Antonios G. Kanaras | Zendy

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Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers

Author(s) -

Maria-Eleni Kyriazi,

Davide Giust,

Afaf H. ElSagheer,

Peter M. Lackie,

Otto L. Muskens,

Tom Brown,

Antonios G. Kanaras

Publication year - 2018

Publication title -

acs nano

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.554

H-Index - 382

eISSN - 1936-086X

pISSN - 1936-0851

DOI - 10.1021/acsnano.7b08620

Subject(s) - drug delivery , colloidal gold , nanoparticle , nanotechnology , dna , multiplexing , nanomedicine , drug , mitoxantrone , materials science , chemistry , computational biology , computer science , biology , biochemistry , pharmacology , genetics , chemotherapy , telecommunications

The design of nanoparticulate systems which can perform multiple synergistic functions in cells with high specificity and selectivity is of great importance in applications. Here we combine recent advances in DNA-gold nanoparticle self-assembly and sensing to develop gold nanoparticle dimers that are able to perform multiplexed synergistic functions within a cellular environment. These dimers can sense two mRNA targets and simultaneously or independently deliver one or two DNA-intercalating anticancer drugs (doxorubicin and mitoxantrone) in live cells. Our study focuses on the design of sophisticated nanoparticle assemblies with multiple and synergistic functions that have the potential to advance sensing and drug delivery in cells.

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