Open AccessInduction of Apoptosis in Cancer Cells by Glutathione Transferase Inhibitor Mediated Hydrophobic Tagging Molecules
Author(s) -
Xiaona Li,
Zirui Lü,
Cong Wang,
Kebin Li,
Fengrong Xu,
Ping Xu,
Yan Niu
Publication year - 2021
Publication title -
acs medicinal chemistry letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 66
ISSN - 1948-5875
DOI - 10.1021/acsmedchemlett.0c00627
Subject(s) - glutathione , apoptosis , cancer cell , glutathione transferase , cancer , chemistry , glutathione s transferase , cancer research , drug resistance , biochemistry , moiety , transferase , enzyme , biology , stereochemistry , genetics
The abnormally high expression of glutathione transferases is closely associated with cancer incidence and drug resistance. By introducing a hydrophobic moiety to the inhibitor structure, we organized a series of degraders of glutathione transferases and demonstrated them potently inducing apoptosis in cancer cells, presenting their pharmacological potential in cancer therapy.