Open AccessEngineering Selectivity for Reduced Toxicity of Bacterial Kinase Inhibitors Using Structure-Guided Medicinal Chemistry
Author(s) -
Nathan Wlodarchak,
John B. Feltenberger,
Zhengqing Ye,
Jeffrey Beczkiewicz,
Rebecca R. Procknow,
Gang Yan,
Troy M. King,
Jennifer E. Golden,
Rob Striker
Publication year - 2021
Publication title -
acs medicinal chemistry letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.065
H-Index - 66
ISSN - 1948-5875
DOI - 10.1021/acsmedchemlett.0c00580
Subject(s) - kinome , toxicity , kinase , zebrafish , drug discovery , chemistry , pharmacology , cyclin dependent kinase , biochemistry , medicine , cell , cell cycle , organic chemistry , gene