Discovery of a Series of Pyrazinone RORγ Antagonists and Identification of the Clinical Candidate BI 730357 | Zendy

Christian Harcken | Zendy; Johanna Csengery | Zendy; Michael Turner | Zendy; Lifen Wu | Zendy; Shuang Liang | Zendy; Robert Sibley | Zendy; Steven Brunette | Zendy; Mark E. Labadia | Zendy; Kathleen Hoyt | Zendy; A. Wayne | Zendy; Thomas Wieckowski | Zendy; Gregg Davis | Zendy; Mark Panzenbeck | Zendy; Donald Souza | Zendy; Stanley Kugler | Zendy; Donna Terenzio | Zendy; Delphine Collin | Zendy; Dustin Smith | Zendy; Ryan M. Fryer | Zendy; YinChao Tseng | Zendy; Jörg P. Hehn | Zendy; Kim Fletcher | Zendy; Robert Hughes | Zendy

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Discovery of a Series of Pyrazinone RORγ Antagonists and Identification of the Clinical Candidate BI 730357

Author(s) -

Christian Harcken,

Johanna Csengery,

Michael Turner,

Lifen Wu,

Shuang Liang,

Robert Sibley,

Steven Brunette,

Mark E. Labadia,

Kathleen Hoyt,

A. Wayne,

Thomas Wieckowski,

Gregg Davis,

Mark Panzenbeck,

Donald Souza,

Stanley Kugler,

Donna Terenzio,

Delphine Collin,

Dustin Smith,

Ryan M. Fryer,

YinChao Tseng,

Jörg P. Hehn,

Kim Fletcher,

Robert Hughes

Publication year - 2021

Publication title -

acs medicinal chemistry letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.065

H-Index - 66

ISSN - 1948-5875

DOI - 10.1021/acsmedchemlett.0c00575

Subject(s) - rar related orphan receptor gamma , retinoic acid , metabolic stability , orphan receptor , pharmacology , interleukin 17 , potency , nuclear receptor , chemistry , transcription factor , medicine , computational biology , biology , immunology , inflammation , biochemistry , in vitro , gene

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