Open AccessTriblock–Diblock Composite Nanoassemblies with Sequentially Addressable Host–Guest Properties for Hydrophobics and Hydrophilics
Author(s) -
Jiaming Zhuang,
S. Thayumanavan
Publication year - 2020
Publication title -
acs macro letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.966
H-Index - 92
ISSN - 2161-1653
DOI - 10.1021/acsmacrolett.0c00290
Subject(s) - micelle , amphiphile , copolymer , materials science , coating , composite number , polymer , hydrophobe , nanocomposite , superhydrophobic coating , nanotechnology , molecule , hydrophobic effect , chemical engineering , non covalent interactions , chemistry , organic chemistry , hydrogen bond , composite material , aqueous solution , engineering
Noncovalent encapsulation of multiple guest molecules with distinct physiochemical properties, especially hydrophilic and hydrophobic guests, into a single polymeric nanoassembly is challenging, but would be profoundly beneficial to combination therapeutic delivery strategies. Here, we report a nanocomposite co-assembled by coating a layer of an amphiphilic block copolymer onto surface of a crosslinked inverse micelle driven by hydrophobic interactions. The hydrophobic coating layer and water-filled inverse micelles were utilized to encapsulate hydrophobic and hydrophilic cargos respectively. Rationally introducing the pH and redox responsive moieties into coating polymer and inverse micelles, allows sequentially addressing triggered release of the encapsulated cargos.